If you drink a couple bottles of red wine in a sitting, chances are the morning will bring with it a splitting headache. This could be for any number of reasons, and the science isn’t exactly clear. All wines contain sulfites, which occur naturally in the winemaking process. Though a small percentage of the population have a sulfite allergy, this usually resembles an asthma attack, not a headache.
The alcohol contained in wine is the most obvious culprit, and the dehydrating effect it has on your body certainly doesn’t help. Your best bet is to proceed with caution, and maybe enjoy a little downtime between glasses.